Noun: chromothripsis
Sample Sentences
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But for 2—3% of cancers, particularly bone cancer (up to 25%), recent evidence suggests that a single event of chromothripsis involving one or a few chromosomes leads to multiple gene rearrangements (in some cases tens to hundreds) that can disrupt tumor suppressor genes and/or produce oncogenic fusion genes. [2012, Lauren Pecorino, Molecular Biology of Cancer: Mechanisms, Targets, and Therapeutics, page 24:]
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Another new phenomenon described by Stephens et al.[86] is called “chromothripsis”. Chromothripsis describes a massive genomic rearrangement in one or more chromosomes in a single catastrophic event during the cells' history, [2014, Asfar Azmi, Molecular Diagnostics and Treatment of Pancreatic Cancer, page 113:]
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Some of the characteristics of chromothripsis are oscillating copy number changes, clustering of breakpoints, localized rearrangements involving one or a part of a chromosome, and complex rearrangements. [2015, Anders M. Lindroth, Yoon Jung Park, Christoph Plass, “Epigenetic Reprogramming in Cancer”, in Alexander Meissner, Jörn Walter, editors, Epigenetic Mechanisms in Cellular Reprogramming, Springer, page 206:]
Nouns inflected like chromothripsis
greyware,
chronotropy,
urgrund,
cytosorting,
homekeeping,
pedobaiting,
winterdress,
JLNS,
rumpology,
hopkinsiaxanthin,
enchylemma,
further education,
hexobendine,
humdrumminess,
unobligingness,
backscroll,
telocinobufagin,
dosulepin,
mensuralism,
crème de framboise, etc. (List truncated at 20 nouns)
Etymology
From Ancient Greek χρῶμα (khrôma, “colour”) (referring to English chromo(some)) + θρίψις (thrípsis, “shattering into pieces”) (from τρίβω (tríbō, “I rub”). See: English Nouns '
chromosome'.